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Food and Drug Administration (FDA) deliver nicotine in a form that does not involve the risks of smoking: transdermal nicotine patches, nicotine gum, nicotine lozenges, nicotine inhalers, nicotine oral sprays, and nicotine nasal sprays.

Nicotine replacement therapy (NRT): Five medications have been approved by the U.S.

The American Cancer Society notes that 'Studies in medical journals have reported that about 25% of smokers who use medicines can stay smoke-free for over 6 months.' Single medications include:

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MedicationsĪ 21mg dose nicotine patch applied to the left arm Studies have found that two-thirds of recent quitters reported using the cold turkey method and found it helpful. In a large British study of ex-smokers in the 1980s, before the advent of pharmacotherapy, 53% of the ex-smokers said that it was 'not at all difficult' to stop, 27% said it was 'fairly difficult', and the remaining 20% found it very difficult. In three studies, it was the quitting method cited by 76%, 85%, or 88% of long-term successful quitters. ' Cold turkey' is a colloquial term indicating abrupt withdrawal from an addictive drug, and in this context indicates sudden and complete cessation of all nicotine use. The most frequent unassisted methods were ' cold turkey', a term that has been used to mean either unassisted quitting or abrupt quitting and 'gradually decreased number' of cigarettes, or 'cigarette reduction'. In the U.S., for example, the rate of unassisted quitting fell from 91.8% in 1986 to 52.1% during 2006 to 2009. The majority of quit attempts are still unassisted, though the trend seems to be shifting. Identifying which approach or technique is eventually most successful is difficult it has been estimated, for example, that only about 4% to 7% of people are able to quit smoking on any given attempt without medicines or other help.

Previous smokers make between an estimated 6 and 30 attempts before successfully quitting. Over 74.7% of smokers attempt to quit without any assistance, otherwise known as 'Cold Turkey', or with home remedies. It is common for ex-smokers to have made a number of attempts (often using different approaches on each occasion) to stop smoking before achieving long-term abstinence. 1.17 People in treatment for or recovery from substance use disorders.

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: 2298 Professional smoking cessation support methods generally attempt to address nicotine withdrawal symptoms to help the person break free of nicotine addiction. In nicotine-dependent smokers, quitting smoking can lead to symptoms of nicotine withdrawal such as nicotine cravings, anxiety, irritability, depression, and weight gain. A meta-analysis from 2018, conducted on 61 randomized controlled trials, showed that among people who quit smoking with a cessation medication (and some behavioral help), approximately 20% were still nonsmokers a year later, as compared to 12% who did not take medication. Behavioral counseling and medications each increase the rate of successfully quitting smoking, and a combination of behavioral counseling with a medication such as bupropion is more effective than either intervention alone. However, only 3–6% of quit attempts without assistance are successful long-term. Most smokers who try to quit do so without assistance. Many strategies can be used for smoking cessation, including abruptly quitting without assistance (' cold turkey'), cutting down then quitting, behavioral counseling, and medications such as bupropion, cytisine, nicotine replacement therapy, or varenicline. Smoking cessation significantly reduces the risk of dying from smoking-related diseases such as coronary heart disease, chronic obstructive pulmonary disease (COPD), and lung cancer. Smoking is the leading preventable cause of death worldwide. In the U.S., about 70% of smokers would like to quit smoking, and 50% report having made an attempt to do so in the past year.

As a result, nicotine withdrawal often makes the process of quitting difficult. Tobacco smoke contains nicotine, which is addictive and can cause dependence. Smoking cessation, usually called quitting smoking or stopping smoking, is the process of discontinuing tobacco smoking.

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